Anesthetics

Important Risk Information about OneTouch Advanced
Hypersensitivity Reactions: Unpredictable adverse reactions (i.e., hypersensitivity, including anaphylaxis) are extremely rare. Localized
allergic reactions may occur after prolonged or repeated use of any aminobenzoate anesthetic. The most common adverse reaction caused
by local anesthetics is contact dermatitis characterized by erythema and pruritus that may progress to vesiculation and oozing. This occurs
most commonly in patients following prolonged self-medication, which is contraindicated. If rash, urticaria, edema, or other manifestations
of allergy develop during use, the drug should be discontinued. To minimize the possibility of a serious allergic reaction, OneTouch
Advanced preparations should not be applied for prolonged periods except under continual supervision. Dehydration of the epithelium or
an escharotic effect may also result from prolonged contact. Precaution: On rare occasions, methemoglobinemia has been reported in
connection with the use of benzocaine-containing products. Care should be used not to exceed the maximum recommended dosage of
400 mg. An appropriate pediatric dosage has not been established for OneTouch Advanced. Dosages should be reduced in the debilitated
elderly, acutely ill, and very young patients. If a patient becomes cyanotic, treat appropriately to counteract (such as with methylene blue,
if medically indicated). Use in Pregnancy: Safe use of OneTouch Advanced has not been established with respect to possible adverse
effects upon fetal development. Therefore, OneTouch Advanced should not be used during early pregnancy, unless in the judgment of a
physician the potential benefits outweigh the unknown hazards. Contraindications: OneTouch Advanced is not suitable and should
never be used for injection. Do not use on the eyes. To avoid excessive systemic absorption, OneTouch Advanced should not be applied to
large areas of denuded or inflamed tissue. OneTouch Advanced should not be administered to patients who are hypersensitive to any of its
ingredients or to patients known to have cholinesterase deficiencies. Tolerance may vary with the status of the patient. OneTouch
Advanced should not be used under dentures or cotton rolls, as retention of the active ingredients under a denture or cotton roll could
possibly cause an escharotic effect. Routine precaution for the use of any topical anesthetic should be observed when using
OneTouch Advanced.